Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.84 |
| ▸ | MAPT | P10636 | 4/20 | 0.84 |
| ▸ | LMNA | P02545 | 4/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.75 |
| ▸ | XBP1 | P17861 | 1/20 | 0.75 |
| ▸ | UBE2N | P61088 | 1/20 | 0.75 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GUSB | P08236 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | MGAM | O43451 | 1/20 | 0.53 |
| ▸ | SI | P14410 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723282 | 0.92 | MAPT (1.00) | KMT2AMAPTLMNAKDM4ETDP1 | |
| SCHEMBL2722489 | 0.91 | MAPT (0.87) | KMT2AMAPTLMNAKDM4ETDP1 | |
| SCHEMBL2724211 | 0.89 | MAPT (0.83) | KMT2AMAPTLMNAKDM4ETDP1 | |
| SCHEMBL2725830 | 0.86 | MAPT (1.00) | KMT2AMAPTLMNAKDM4ETDP1 | |
| SCHEMBL2722076 | 0.86 | KMT2A (0.84) | KMT2AMAPTLMNAKDM4ETDP1 | |
| SCHEMBL2722837 | 0.85 | MAPT (0.79) | KMT2AMAPTLMNAKDM4ETDP1 | |
| SCHEMBL2722291 | 0.84 | MAPT (0.81) | KMT2AMAPTLMNAKDM4ETDP1 | |
| SCHEMBL10289182 | 0.84 | MAPT (0.96) | KMT2AMAPTLMNAKDM4ETDP1 | |
| SCHEMBL16662442 | 0.84 | MAPT (0.75) | KMT2AMAPTLMNAKDM4ETDP1 | |
| SCHEMBL2725485 | 0.82 | MAPT (0.73) | KMT2AMAPTLMNAKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632466-A2 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | Emory University (US) | 2013-09-04 | — | — | EP | claimed |
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2013-08-29 | — | — | US | claimed |
| WO-2012058211-A2 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2012-05-03 | — | — | WO | claimed |
| US-9868728-B2 | Quinazoline derivatives, compositions, and uses related thereto | EMORY UNIVERSITY (US) | 2018-01-16 | — | — | US | disclosed |
| EP-2886120-A1 | Quinazoline derivatives, compositions and uses related thereto | Emory University (US) | 2015-06-24 | — | — | EP | disclosed |
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2013-08-29 | — | — | US | disclosed |
| WO-2012058211-A2 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | NOX4, NOX5, NQO2 | KMT2A 1366/4885MAPT 1860/4885LMNA 4042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.