Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
| ▸ | TUBB | P07437 | 1/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25112482 | 0.89 | KDM4E (0.54) | KDM4EGAATDP1LMNAMAPK1 | |
| SCHEMBL27167377 | 0.86 | KDM4E (0.72) | KDM4EGAATDP1LMNAMAPK1 | |
| SCHEMBL2722306 | 0.85 | KDM4E (0.67) | KDM4EGAATDP1LMNAMAPK1 | |
| SCHEMBL24792433 | 0.85 | KDM4E (0.67) | KDM4EGAATDP1LMNAMAPK1 | |
| SCHEMBL29900596 | 0.85 | KDM4E (0.67) | KDM4EGAATDP1LMNAMAPK1 | |
| SCHEMBL6120242 | 0.82 | KDM4E (0.71) | KDM4EGAATDP1LMNAMAPK1 | |
| SCHEMBL28875071 | 0.80 | KDM4E (0.64) | KDM4EGAATDP1LMNAMAPK1 | |
| SCHEMBL6128121 | 0.78 | KDM4E (0.62) | KDM4EGAATDP1LMNAMAPK1 | |
| SCHEMBL23882078 | 0.77 | KDM4E (0.54) | KDM4EGAATDP1LMNAMAPK1 | |
| SCHEMBL31716637 | 0.77 | KDM4E (0.57) | KDM4EGAATDP1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052556-A1 | NOVEL HALOALKOXYQUINAZOLINES, AND PREPARATION AND USE THEREOF | UNIVERSITÄT LEIPZIG (DE) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012052556-A1 | NOVEL HALOALKOXYQUINAZOLINES, AND PREPARATION AND USE THEREOF | UNIVERSITÄT LEIPZIG (DE) | 2012-04-26 | — | — | WO | disclosed |