Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | HBB | P68871 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27167377 | 0.84 | KDM4E (0.72) | KDM4EGAAMAPK1USP2ALDH1A1 | |
| SCHEMBL2722552 | 0.80 | KDM4E (0.67) | KDM4EGAAMAPK1USP2ALDH1A1 | |
| SCHEMBL2722306 | 0.80 | KDM4E (0.67) | KDM4EGAAMAPK1USP2ALDH1A1 | |
| SCHEMBL24792433 | 0.80 | KDM4E (0.67) | KDM4EGAAMAPK1USP2ALDH1A1 | |
| SCHEMBL29900596 | 0.80 | KDM4E (0.67) | KDM4EGAAMAPK1USP2ALDH1A1 | |
| SCHEMBL6120242 | 0.78 | KDM4E (0.71) | KDM4EGAAMAPK1USP2ALDH1A1 | |
| SCHEMBL28307055 | 0.78 | PARP1 (0.41) | KDM4EGAAMAPK1PARP1 | |
| SCHEMBL7415916 | 0.77 | PARP1 (0.63) | KDM4EGAAUSP2PARP1LMNA | |
| SCHEMBL19846637 | 0.76 | PARP1 (0.60) | PARP1 | |
| SCHEMBL2266470 | 0.76 | PDE10A (0.55) | KDM4EGAAALDH1A1TDP1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110041306-A | 4- hydroxyl -2- quinolone-nitrogen-(4- quinazolinone) -3- carboxamides derivatives | 中国医学科学院药物研究所 | 2019-07-23 | — | — | CN | disclosed |