Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2481350 | 0.82 | SLC22A12 (0.38) | SLC22A12NOTUMXIAPBIRC2 | |
| SCHEMBL2720836 | 0.78 | ESPL1 (0.39) | SLC22A12 | |
| SCHEMBL447188 | 0.78 | NOTUM (0.50) | SLC22A12NOTUMBIRC2 | |
| SCHEMBL1042950 | 0.74 | NOTUM (0.62) | SLC22A12NOTUMXIAPBIRC2 | |
| SCHEMBL22346077 | 0.74 | KMT2A (0.42) | SLC22A12 | |
| SCHEMBL27635870 | 0.74 | SLC6A2 (0.32) | NOTUM | |
| SCHEMBL1612802 | 0.70 | NOTUM (0.39) | NOTUMXIAPBIRC2 | |
| SCHEMBL27635869 | 0.68 | NOTUM (0.37) | SLC22A12NOTUMXIAPBIRC2 | |
| SCHEMBL12713555 | 0.68 | PDE4B (0.35) | — | |
| SCHEMBL2912534 | 0.66 | KMT2A (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445902-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES AS INHIBITORS OF PI3K ACTIVITY | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151737-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |