Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 8/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8372465 | 0.97 | CHRM2 (0.39) | SLC2A1CHRM2NPSR1DNM1MEN1 | |
| SCHEMBL34566 | 0.97 | — | — | |
| Ammonia Solution, Strong SCHEMBL9175333 | 0.94 | CHRM2 (0.38) | SLC2A1CHRM2NPSR1DNM1MEN1 | |
| Hydrochloric Acid SCHEMBL2673866 | 0.94 | DNM1 (0.41) | SLC2A1CHRM2NPSR1DNM1MEN1 | |
| Hydrochloric Acid SCHEMBL27743917 | 0.94 | DNM1 (0.41) | SLC2A1CHRM2NPSR1DNM1MEN1 | |
| Methane SCHEMBL14937689 | 0.94 | CHRM2 (0.38) | SLC2A1CHRM2NPSR1DNM1MEN1 | |
| SCHEMBL2847437 | 0.92 | LCK (0.39) | SLC2A1CHRM2NPSR1DNM1MEN1 | |
| SCHEMBL11075643 | 0.92 | NPSR1 (0.36) | SLC2A1CHRM2NPSR1DNM1MEN1 | |
| SCHEMBL9640593 | 0.92 | NPSR1 (0.36) | SLC2A1CHRM2NPSR1DNM1MEN1 | |
| SCHEMBL15069 | 0.91 | CHRM2 (0.39) | CHRM2NPSR1DNM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11365332-B2 | Plastic adhesion promotion for 2K polyurethane adhesives | HENKEL AG & CO. KGAA (DE) | 2022-06-21 | — | — | US | disclosed |
| US-10920042-B2 | Method for preparing a hydrophobically modified clay | HENKEL AG & CO. KGAA (DE) | 2021-02-16 | — | — | US | disclosed |
| EP-3504252-A1 | PLASTIC ADHESION PROMOTION FOR 2K POLYURETHANE ADHESIVES | Henkel AG & Co. KGaA (DE) | 2019-07-03 | — | — | EP | disclosed |
| EP-3500625-A1 | METHOD FOR PREPARING A HYDROPHOBICALLY MODIFIED CLAY | Henkel AG & Co. KGaA (DE) | 2019-06-26 | — | — | EP | disclosed |
| US-20190177511-A1 | METHOD FOR PREPARING A HYDROPHOBICALLY MODIFIED CLAY | HENKEL AG & CO. KGAA (DE) | 2019-06-13 | — | — | US | disclosed |
| US-20190177583-A1 | Plastic Adhesion Promotion for 2K Polyurethane Adhesives | HENKEL AG & CO. KGAA (DE) | 2019-06-13 | — | — | US | disclosed |
| EP-3287477-B1 | PLASTIC ADHESION PROMOTION FOR 2K POLYURETHANE ADHESIVES | HENKEL AG & CO KGAA (DE) | 2019-06-12 | — | — | EP | disclosed |
| WO-2018036849-A1 | PLASTIC ADHESION PROMOTION FOR 2K POLYURETHANE ADHESIVES | HENKEL AG & CO. KGAA (DE) | 2018-03-01 | — | — | WO | disclosed |
| EP-3287477-A1 | PLASTIC ADHESION PROMOTION FOR 2K POLYURETHANE ADHESIVES | Henkel AG & Co. KGaA (DE) | 2018-02-28 | — | — | EP | disclosed |
| WO-2018033551-A1 | METHOD FOR PREPARING A HYDROPHOBICALLY MODIFIED CLAY | HENKEL AG & CO. KGAA (DE) | 2018-02-22 | — | — | WO | disclosed |
| US-8791184-B2 | Two-component polyurethane adhesives with thixotropic effect | HENKEL AG & CO. KGAA (DE) | 2014-07-29 | — | — | US | disclosed |
| EP-2635618-A1 | TWO-COMPONENT POLYURETHANE ADHESIVES WITH I TROPIC EFFECT | Henkel (China) Co. Ltd. (CN) | 2013-09-11 | — | — | EP | disclosed |
| US-20130186559-A1 | TWO-COMPONENT POLYURETHANE ADHESIVES WITH THIXOTROPIC EFFECT | Henkel (China) Co. Ltd. (CN) | 2013-07-25 | — | — | US | disclosed |
| WO-2012058806-A1 | TWO-COMPONENT POLYURETHANE ADHESIVES WITH ΤΗIΧΟTROPIC EFFECT | HENKEL CHINA CO. LTD. (CN) | 2012-05-10 | — | — | WO | disclosed |