Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9956787 | 0.91 | HSP90AA1 (0.51) | PTGS2PTGS1HSP90AA1GPBAR1LMNA | |
| SCHEMBL2722592 | 0.88 | PTGS1 (0.69) | PTGS2PTGS1GPBAR1LMNAMAPT | |
| SCHEMBL4549984 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1HSP90AA1GPBAR1LMNA | |
| SCHEMBL2723070 | 0.87 | TP53 (0.47) | PTGS2PTGS1HSP90AA1GPBAR1LMNA | |
| SCHEMBL2720986 | 0.83 | PTGS1 (0.52) | PTGS2PTGS1HSP90AA1GPBAR1LMNA | |
| SCHEMBL2721067 | 0.83 | GPBAR1 (0.47) | PTGS2PTGS1HSP90AA1GPBAR1LMNA | |
| SCHEMBL2732395 | 0.83 | PTGS1 (0.59) | PTGS2PTGS1LMNAMAPTS1PR1 | |
| SCHEMBL2721647 | 0.83 | PTGS2 (0.45) | PTGS2PTGS1HSP90AA1GPBAR1LMNA | |
| SCHEMBL5729672 | 0.79 | PTGS2 (0.70) | PTGS2PTGS1 | |
| SCHEMBL10080406 | 0.79 | PTGS1 (0.65) | PTGS2PTGS1GPBAR1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052395-A1 | ISOXAZOLE DERIVATIVES USED AS OESTROGEN MODULATORS | N. V. ORGANON (NL) | 2012-04-26 | — | — | WO | disclosed |