Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | RPS6KA2 | Q15349 | 5/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2724128 | 0.92 | HSD17B10 (0.56) | HSD17B10BRD4POLBALDH1A1KMT2A | |
| SCHEMBL2725872 | 0.83 | HSD17B10 (0.57) | HSD17B10POLBALDH1A1KMT2AIRAK4 | |
| SCHEMBL18263887 | 0.79 | HSD17B10 (0.67) | HSD17B10POLBALDH1A1KMT2AIRAK4 | |
| SCHEMBL2725093 | 0.77 | HSD17B10 (0.67) | HSD17B10POLBALDH1A1KMT2AIRAK4 | |
| SCHEMBL9109386 | 0.77 | HDAC6 (0.54) | HSD17B10POLBALDH1A1KMT2APDE11A | |
| SCHEMBL2724437 | 0.77 | HSD17B10 (0.74) | HSD17B10POLBALDH1A1KMT2AIRAK4 | |
| SCHEMBL24890579 | 0.74 | NAMPT (0.57) | ALDH1A1KMT2ALMNANPC1RAB9A | |
| SCHEMBL248347 | 0.73 | CACNA1B (0.57) | ALDH1A1KMT2ANAMPT | |
| SCHEMBL2829176 | 0.72 | POLB (0.56) | POLBALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL30944753 | 0.72 | F10 (0.48) | ALDH1A1KMT2AGAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10590088-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and methods of synthesis thereof | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190084940-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2019-03-21 | — | — | US | disclosed |
| US-20160362382-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2016-12-15 | — | — | US | disclosed |
| US-9464059-B2 | Benzamide derivatives | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2016-10-11 | — | — | US | disclosed |
| US-20150284336-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2015-10-08 | — | — | US | disclosed |
| US-9125901-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and salts or solvates thereof | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-09-08 | — | — | US | disclosed |
| EP-2445345-B1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RES INST (US) | 2014-08-27 | — | — | EP | disclosed |
| US-20120142922-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2012-06-07 | — | — | US | disclosed |
| EP-2445345-A1 | BENZAMIDE DERIVATIVES | The Translational Genomics Research Institute (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151441-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2010-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590088-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and methods of synthesis thereof | MCL1, BRDT, BOD1L1 | HSD17B10 2881/4885BRD4 17/4885POLB 1663/4885 |
| US-20120142922-A1 | BENZAMIDE DERIVATIVES | BRDT, BRD3, BRD2 | HSD17B10 2696/4885BRD4 6/4885POLB 351/4885 |
| US-20150284336-A1 | BENZAMIDE DERIVATIVES | BRDT, BRD3, BRD2 | HSD17B10 2696/4885BRD4 6/4885POLB 351/4885 |
| US-20160362382-A1 | BENZAMIDE DERIVATIVES | BRDT, BRD3, BRD2 | HSD17B10 2696/4885BRD4 6/4885POLB 351/4885 |
| US-20190084940-A1 | BENZAMIDE DERIVATIVES | BRDT, BRD3, BRD2 | HSD17B10 2696/4885BRD4 6/4885POLB 351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.