Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9109386 | 0.92 | HDAC6 (0.54) | HSD17B10ALDH1A1KMT2APOLBHDAC1 | |
| SCHEMBL9910547 | 0.88 | PDE11A (0.58) | HSD17B10ALDH1A1HDAC1HDAC2HDAC3 | |
| SCHEMBL18263887 | 0.83 | HSD17B10 (0.67) | HSD17B10ALDH1A1KMT2APOLBHDAC1 | |
| SCHEMBL2724129 | 0.83 | HSD17B10 (0.52) | HSD17B10ALDH1A1KMT2APOLBIRAK4 | |
| SCHEMBL12974295 | 0.82 | KDM4E (0.63) | HSD17B10ALDH1A1KMT2AIRAK4NPC1 | |
| SCHEMBL2726254 | 0.81 | TP53 (0.56) | HSD17B10ALDH1A1KMT2AHDAC1HDAC2 | |
| SCHEMBL2724437 | 0.81 | HSD17B10 (0.74) | HSD17B10ALDH1A1KMT2APOLBIRAK4 | |
| SCHEMBL4982506 | 0.79 | HDAC1 (0.60) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL2725093 | 0.78 | HSD17B10 (0.67) | HSD17B10ALDH1A1KMT2APOLBIRAK4 | |
| SCHEMBL18132836 | 0.76 | NPC1 (0.60) | HSD17B10ALDH1A1KMT2APOLBPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160362382-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2016-12-15 | — | — | US | claimed |
| US-9125901-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and salts or solvates thereof | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-09-08 | — | — | US | claimed |
| US-10590088-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and methods of synthesis thereof | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2020-03-17 | — | — | US | disclosed |
| US-10590088-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and methods of synthesis thereof | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190084940-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2019-03-21 | — | — | US | disclosed |
| US-20190084940-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2019-03-21 | — | — | US | disclosed |
| US-20160362382-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2016-12-15 | — | — | US | disclosed |
| US-20160362382-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2016-12-15 | — | — | US | disclosed |
| US-20160362382-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2016-12-15 | — | — | US | disclosed |
| US-9464059-B2 | Benzamide derivatives | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2016-10-11 | — | — | US | disclosed |
| US-9464059-B2 | Benzamide derivatives | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2016-10-11 | — | — | US | disclosed |
| US-9125901-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and salts or solvates thereof | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-09-08 | — | — | US | disclosed |
| EP-2445345-B1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RES INST (US) | 2014-08-27 | — | — | EP | disclosed |
| EP-2445345-B1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RES INST (US) | 2014-08-27 | — | — | EP | disclosed |
| US-20120142922-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2012-06-07 | — | — | US | disclosed |
| US-20120142922-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2012-06-07 | — | — | US | disclosed |
| US-20120142922-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2012-06-07 | — | — | US | disclosed |
| EP-2445345-A1 | BENZAMIDE DERIVATIVES | The Translational Genomics Research Institute (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151441-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2010-12-29 | — | — | WO | disclosed |
| WO-2010151441-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2010-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590088-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and methods of synthesis thereof | MCL1, BRDT, BOD1L1 | HSD17B10 2881/4885ALDH1A1 400/4885KMT2A 370/4885 |
| US-20120142922-A1 | BENZAMIDE DERIVATIVES | BRDT, BRD3, BRD2 | HSD17B10 2696/4885ALDH1A1 592/4885KMT2A 520/4885 |
| US-20160362382-A1 | BENZAMIDE DERIVATIVES | BRDT, BRD3, BRD2 | HSD17B10 2696/4885ALDH1A1 592/4885KMT2A 520/4885 |
| US-20190084940-A1 | BENZAMIDE DERIVATIVES | BRDT, BRD3, BRD2 | HSD17B10 2696/4885ALDH1A1 592/4885KMT2A 520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.