Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 6/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.36 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23293768 | 0.90 | KDM4E (0.56) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL29800261 | 0.90 | KDM4E (0.56) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL30947730 | 0.89 | MAPT (0.43) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL23316231 | 0.89 | MAPT (0.43) | KDM4EALDH1A1MAPTMEN1POLB | |
| Hydrochloric Acid SCHEMBL23293837 | 0.89 | KDM4E (0.56) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL23293858 | 0.88 | KDM4E (0.45) | KDM4EALDH1A1MAPTMEN1POLB | |
| Succinic Acid SCHEMBL23293781 | 0.88 | KDM4E (0.51) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL23293821 | 0.87 | KDM4E (0.45) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL29800591 | 0.87 | KDM4E (0.45) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL23316314 | 0.87 | KDM4E (0.45) | KDM4EALDH1A1MAPTMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12012410-B2 | Substituted pyrazolo[1,5-a]pyrazines for spinal muscular atrophy | REBORNA BIOSCIENCES, INC. (JP) | 2024-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12012410-B2 | Substituted pyrazolo[1,5-a]pyrazines for spinal muscular atrophy | SMN1; SMN2, HDAC5, PUM1 | KDM4E 1818/4885ALDH1A1 1801/4885MAPT 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.