Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27242607 | 0.90 | PTGER4 (0.53) | ROCK1ROCK2PTGER4CSNK2A1KDM4E | |
| SCHEMBL27242430 | 0.90 | PTGER4 (0.51) | ROCK1ROCK2PTGER4CSNK2A1KDM4E | |
| SCHEMBL27242584 | 0.86 | ROCK1 (0.49) | ROCK1ROCK2PTGER4KDM4EMEN1 | |
| SCHEMBL27242775 | 0.85 | ROCK1 (0.44) | ROCK1ROCK2PTGER4GRM4CREBBP | |
| SCHEMBL27242456 | 0.85 | ROCK1 (0.44) | ROCK1ROCK2PTGER4GRM4CREBBP | |
| SCHEMBL27242476 | 0.84 | ROCK2 (0.48) | ROCK1ROCK2PTGER4CSNK2A1KDM4E | |
| SCHEMBL30895629 | 0.84 | ROCK2 (0.46) | ROCK1ROCK2PTGER4CSNK2A1KDM4E | |
| SCHEMBL24757352 | 0.83 | NR1H2 (0.41) | NR1H2GRM4KDM4EMAPK1TDP1 | |
| SCHEMBL27242530 | 0.82 | PTGER4 (0.51) | ROCK1ROCK2PTGER4KDM4EMEN1 | |
| SCHEMBL30895659 | 0.81 | IDH1 (0.49) | ROCK1ROCK2PTGER4KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4385980-A1 | INDAZOLES AS INHIBITORS OF NAV1.8 | Grünenthal GmbH (DE) | 2024-06-19 | — | — | EP | disclosed |