Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | STAT3 | P40763 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1216515 | 0.84 | KDM4E (0.59) | KDM4ESTAT3HIF1ANR4A2SMN1; SMN2 | |
| SCHEMBL5945726 | 0.84 | KDM4E (0.59) | KDM4ESTAT3HIF1ANR4A2SMN1; SMN2 | |
| SCHEMBL18512242 | 0.84 | KDM4E (0.59) | KDM4ESTAT3HIF1ANR4A2SMN1; SMN2 | |
| SCHEMBL7356720 | 0.84 | KDM4E (0.59) | KDM4ESTAT3HIF1ASMN1; SMN2MAPT | |
| SCHEMBL31647147 | 0.84 | KDM4E (0.59) | KDM4ESTAT3HIF1ANR4A2SMN1; SMN2 | |
| SCHEMBL16235687 | 0.81 | MCL1 (0.46) | KDM4ENR4A2SMN1; SMN2MAPTBRPF1 | |
| SCHEMBL16255977 | 0.80 | BRPF1 (0.42) | KDM4ESTAT3HIF1ANR4A2SMN1; SMN2 | |
| SCHEMBL27242653 | 0.80 | PDK2 (0.54) | KDM4ESTAT3HIF1ASMN1; SMN2POLB | |
| SCHEMBL498053 | 0.77 | KDM4E (1.00) | KDM4ESTAT3HIF1ASMN1; SMN2MAPT | |
| SCHEMBL29805260 | 0.77 | KDM4E (1.00) | KDM4ESTAT3HIF1ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4385980-A1 | INDAZOLES AS INHIBITORS OF NAV1.8 | Grünenthal GmbH (DE) | 2024-06-19 | — | — | EP | disclosed |