Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LGMN | Q99538 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2124487 | 0.90 | PIK3CA (0.49) | PRKDCNOTUMMAPTLGMNMEN1 | |
| SCHEMBL2126046 | 0.87 | PIK3CA (0.44) | PRKDCNOTUMMAPTLGMNMEN1 | |
| SCHEMBL2123409 | 0.85 | NOTUM (0.52) | PRKDCNOTUMMAPTLGMNMEN1 | |
| SCHEMBL1612985 | 0.78 | NOTUM (0.48) | NOTUMMAPT | |
| SCHEMBL2126993 | 0.77 | PIK3CA (0.46) | PRKDCLGMNMEN1KMT2APIK3CA | |
| SCHEMBL2729800 | 0.75 | IDH1 (0.41) | PRKDCLGMNMEN1KMT2APIK3CA | |
| SCHEMBL17436499 | 0.72 | PDE4B (0.53) | NOTUM | |
| SCHEMBL2608566 | 0.72 | NOTUM (0.57) | PRKDCNOTUMMAPTLGMNMEN1 | |
| SCHEMBL5065354 | 0.72 | PRKDC (0.50) | PRKDCNOTUMMAPTLGMNMEN1 | |
| SCHEMBL2124036 | 0.71 | PIK3CA (0.42) | LGMNMEN1KMT2APIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445902-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES AS INHIBITORS OF PI3K ACTIVITY | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151737-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |