Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | LGMN | Q99538 | 4/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2124036 | 0.88 | PIK3CA (0.42) | IDH1LGMNGPR119ABHD6PIK3CA | |
| SCHEMBL2731130 | 0.81 | KDM1A (0.39) | ABHD6USP30KDM1A | |
| SCHEMBL2124487 | 0.77 | PIK3CA (0.49) | LGMNPIK3CAPIK3CDPIK3CBMEN1 | |
| SCHEMBL22471426 | 0.77 | PIK3CA (0.40) | PIK3CAUSP30KDM1A | |
| SCHEMBL29966436 | 0.77 | PIK3CA (0.40) | PIK3CAUSP30KDM1A | |
| SCHEMBL28521491 | 0.77 | NR1H2 (0.42) | PIK3CAPIK3CDPIK3CBUSP30KDM1A | |
| SCHEMBL2724366 | 0.75 | PRKDC (0.46) | LGMNABHD6PIK3CAPIK3CDPIK3CB | |
| SCHEMBL2123930 | 0.75 | PIK3CA (0.56) | IDH1PIK3CA | |
| SCHEMBL30898670 | 0.74 | NOTUM (0.53) | KDM1A | |
| SCHEMBL15676941 | 0.74 | NOTUM (0.53) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445902-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES AS INHIBITORS OF PI3K ACTIVITY | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151737-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |