Sugi Predict

Sugi Predict / Compounds / SCHEMBL27249697

SCHEMBL27249697

SCHEMBL27249697

CCN(C)C(=O)c1cn(C)c2ccccc12

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.57
▸ ALDH1A1 P00352 2/20 0.57
▸ MAPT P10636 2/20 0.57
▸ MITF O75030 1/20 0.57
▸ KMT2A Q03164 1/20 0.57
▸ NPSR1 Q6W5P4 1/20 0.57
▸ NR4A2 P43354 1/20 0.55
▸ POLB P06746 1/20 0.55
▸ HTT P42858 1/20 0.54
▸ SMN1; SMN2 Q16637 1/20 0.49
▸ PTPN7 P35236 1/20 0.47
▸ DUSP3 P51452 1/20 0.47
▸ MAPK14 Q16539 1/20 0.47
▸ TNF P01375 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27249696 0.86 PTPN7 (0.61) LMNAALDH1A1MAPTMITFKMT2A
SCHEMBL27249475 0.85 LMNA (0.55) LMNAALDH1A1MAPTMITFKMT2A
SCHEMBL29334973 0.85 LMNA (0.55) LMNAALDH1A1MAPTMITFKMT2A
SCHEMBL27249692 0.84 NR4A2 (0.61) LMNAALDH1A1MAPTMITFKMT2A
SCHEMBL27249875 0.83 LMNA (0.52) LMNAALDH1A1MAPTMITFKMT2A
SCHEMBL27249479 0.82 NR4A2 (0.56) LMNAALDH1A1MAPTMITFKMT2A
SCHEMBL27249469 0.80 LMNA (0.50) LMNAALDH1A1MAPTMITFKMT2A
SCHEMBL9165567 0.79 POLB (0.59) LMNAALDH1A1MAPTMITFKMT2A
SCHEMBL13694124 0.79 NR4A2 (0.63) LMNAALDH1A1MAPTMITFKMT2A
SCHEMBL4106159 0.78 KMT2A (0.73) LMNAALDH1A1MAPTMITFKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240239801-A1 PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF Université de Montréal (CA) 2024-07-18 — — US disclosed
US-20240239801-A1 PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF Université de Montréal (CA) 2024-07-18 — — US disclosed
US-20240217971-A1 PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE Université de Montréal (CA) 2024-07-04 — — US disclosed
US-20240217971-A1 PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE Université de Montréal (CA) 2024-07-04 — — US disclosed
WO-2024077391-A1 THIAZOLO[5,4-D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF UNIVERSITE DE MONTREAL (CA) 2024-04-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239801-A1 PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF NRAS, BRAF, KRAS LMNA 3697/4885ALDH1A1 1786/4885MAPT 3495/4885
US-20240217971-A1 PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE BRAF, NRAS, DPYD LMNA 2678/4885ALDH1A1 1619/4885MAPT 3015/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.