Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2725116 | 1.00 | MAPT (0.36) | MAPTJAK3IGF1R | |
| SCHEMBL2694331 | 0.90 | IGF1R (0.38) | MAPTJAK3IGF1R | |
| SCHEMBL2696351 | 0.90 | MAPT (0.37) | MAPTJAK3 | |
| SCHEMBL2696352 | 0.90 | MAPT (0.37) | MAPTJAK3 | |
| SCHEMBL2694334 | 0.90 | IGF1R (0.38) | MAPTJAK3IGF1R | |
| SCHEMBL2697391 | 0.88 | — | — | |
| SCHEMBL2696380 | 0.87 | MAPT (0.35) | MAPTJAK3IGF1R | |
| SCHEMBL2697081 | 0.87 | GPR119 (0.40) | — | |
| SCHEMBL2697080 | 0.87 | GPR119 (0.40) | — | |
| SCHEMBL2696378 | 0.87 | MAPT (0.35) | MAPTJAK3IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635560-B1 | DIHYDROOXAZOL-2-AMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2015-09-30 | — | — | EP | disclosed |
| EP-2635560-A1 | DIHYDROOXAZOL-2-AMINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012059371-A1 | DIHYDROOXAZOL-2-AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-05-10 | — | — | WO | disclosed |