Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.49 |
| ▸ | YAP1 | P46937 | 1/20 | 0.49 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30839909 | 0.92 | TEAD1 (0.49) | TEAD1YAP1TNNI3KTLR2TLR1 | |
| SCHEMBL27255427 | 0.92 | TEAD1 (0.49) | TEAD1YAP1TNNI3KTLR2TLR1 | |
| SCHEMBL27255547 | 0.89 | TEAD1 (0.49) | TEAD1YAP1TNNI3KTLR2TLR1 | |
| SCHEMBL27255432 | 0.88 | TEAD1 (0.48) | TEAD1YAP1TNNI3KTLR2TLR1 | |
| SCHEMBL27255533 | 0.87 | TEAD1 (0.45) | TEAD1YAP1TNNI3KTLR2TLR1 | |
| SCHEMBL27255195 | 0.87 | TEAD1 (0.64) | TEAD1YAP1TNNI3KTLR2TLR1 | |
| SCHEMBL27255368 | 0.86 | TEAD1 (0.44) | TEAD1YAP1TNNI3KTLR2TLR1 | |
| SCHEMBL31591338 | 0.85 | TEAD1 (0.49) | TEAD1YAP1TNNI3KTLR2TLR1 | |
| SCHEMBL27255220 | 0.85 | TEAD1 (0.49) | TEAD1YAP1TNNI3KTLR2TLR1 | |
| SCHEMBL31591372 | 0.83 | TEAD1 (0.45) | TEAD1YAP1TNNI3KTLR2TLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120051465-A | Novel heterobicyclic compounds for inhibiting YAP-TEAD interactions and pharmaceutical compositions containing the same | 韩美药品株式会社 | 2025-05-27 | — | — | CN | claimed |
| CN-120051465-A | Novel heterobicyclic compounds for inhibiting YAP-TEAD interactions and pharmaceutical compositions containing the same | 韩美药品株式会社 | 2025-05-27 | — | — | CN | disclosed |
| WO-2024080792-A1 | NOVEL HETEROBICYCLIC COMPOUND FOR INHIBITING YAP-TEAD INTERACTION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | HANMI PHARM. CO., LTD. (KR) | 2024-04-18 | — | — | WO | disclosed |