Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | CPT2 | P23786 | 1/20 | 0.32 |
| ▸ | CPT1A | P50416 | 1/20 | 0.32 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.32 |
| ▸ | CPS1 | P31327 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.32 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.31 |
| ▸ | SCD | O00767 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468229 | 0.95 | BACE1 (0.37) | BACE1BACE2SMN1; SMN2USP30TRPV1 | |
| SCHEMBL6465415 | 0.92 | BACE1 (0.48) | BACE1BACE2USP30TRPV1CPT2 | |
| SCHEMBL2727473 | 0.92 | BACE1 (0.48) | BACE1BACE2USP30TRPV1CPT2 | |
| SCHEMBL2727474 | 0.92 | BACE1 (0.48) | BACE1BACE2USP30TRPV1CPT2 | |
| SCHEMBL2725028 | 0.89 | BACE1 (0.37) | BACE1BACE2SMN1; SMN2USP30TRPV1 | |
| SCHEMBL2726988 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2TRPV1CPT2CPT1ACPT1B | |
| SCHEMBL2726507 | 0.84 | BACE1 (0.41) | BACE1BACE2SMN1; SMN2TRPV1CPT1A | |
| SCHEMBL2726509 | 0.84 | BACE1 (0.41) | BACE1BACE2SMN1; SMN2TRPV1CPT1A | |
| SCHEMBL2726505 | 0.84 | BACE1 (0.41) | BACE1BACE2SMN1; SMN2TRPV1CPT1A | |
| SCHEMBL2726356 | 0.84 | TRPV1 (0.35) | SMN1; SMN2TRPV1CPT2CPT1ACPT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |