⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetone SCHEMBL28860685 | 0.92 | TRPA1 (0.50) | — | |
| Bromoethane SCHEMBL27589223 | 0.87 | — | — | |
| Acetic Acid SCHEMBL6699654 | 0.87 | — | — | |
| Acetone SCHEMBL28217287 | 0.86 | TRPA1 (0.44) | — | |
| Acetone SCHEMBL8019670 | 0.84 | — | — | |
| Acetamide SCHEMBL7008506 | 0.84 | — | — | |
| Pyruvate SCHEMBL27721572 | 0.81 | — | — | |
| Acetic Acid SCHEMBL11460405 | 0.81 | FFAR3 (0.50) | — | |
| Acetone SCHEMBL28304157 | 0.80 | — | — | |
| Bicarbonate SCHEMBL28150887 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 505 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110128419-A | A kind of difluoro pyrazole heterocycle carboxamides derivatives and its preparation method and application | 南开大学 | 2019-08-16 | — | — | CN | claimed |
| CN-105682461-B | Pesticidal combination and relative method | 美国陶氏益农公司 | 2019-06-14 | — | — | CN | claimed |
| CN-108218809-A | A kind of synthetic method of medicine intermediate thiazolamine -4- Ethyl formates | 邳州易萨新型材料有限公司 | 2018-06-29 | — | — | CN | claimed |
| CN-105130980-B | N-3- benzimidazole thiazole amines derivatives and preparation method and application | 沈阳药科大学 | 2018-05-22 | — | — | CN | claimed |
| CN-104650060-B | A kind of piperidines thiazole and its production and use | 南开大学 | 2018-04-03 | — | — | CN | claimed |
| CN-105439978-B | The preparation method of Acotiamide intermediate | 山东金城医药化工股份有限公司 | 2018-02-16 | — | — | CN | claimed |
| CN-107417639-A | A kind of preparation method of the formic acid of thiazole 4 | 合肥利夫生物科技有限公司 | 2017-12-01 | — | — | CN | claimed |
| CN-105682461-A | Pesticidal compositions and related methods | 美国陶氏益农公司 | 2016-06-15 | — | — | CN | claimed |
| CN-105439978-A | Preparation method of acotiamide intermediate | SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL CO LTD | 2016-03-30 | — | — | CN | claimed |
| CN-105440041-A | Synthetic method of 7-tert-butyl-2-ethyl-8-methyl-5,6-glyoxalidine[1,2-a] pyrazine-2,7(8H)-dicarboxylic acid | WUXI APPTEC CO LTD | 2016-03-30 | — | — | CN | claimed |
| CN-103601742-B | A kind of Largazole analogue, its preparation method and application thereof | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2016-01-20 | — | — | CN | claimed |
| CN-105130980-A | N-3-benzimidazole thiazole amine derivative and preparation method and application thereof | UNIV SHENYANG PHARMACEUTICAL | 2015-12-09 | — | — | CN | claimed |
| CN-102015026-B | The Compounds and methods for of the antiport suppressing NHE to mediate in treatment with fluid retention or salt over loading relevant disease and gastroenteropathy | MERCK PATENT GMBH (DE) | 2015-11-25 | — | — | CN | claimed |
| CN-101981179-B | Yeast mutant strain and yeast extract | KOHJIN CO.,LTD. (JP) | 2015-07-29 | — | — | CN | claimed |
| CN-104650060-A | Piperidine thiazole derivatives as well as preparation method and use of piperidinethiazole derivatives | UNIV NANKAI | 2015-05-27 | — | — | CN | claimed |
| CN-103601742-A | Largazole analogue, and preparation method and applications thereof | GUANGZHOU INST BIOMED & HEALTH | 2014-02-26 | — | — | CN | claimed |
| CN-102898369-A | 3-amino-7-bromoquinoline-2-ethyl formate and preparation method thereof | SHANGHAI SHUYA MEDICAL TECHNOLOGY CO LTD | 2013-01-30 | — | — | CN | claimed |
| CN-102775368-A | Thiazole compound, and preparation method and application thereof | SHANGHAI INST MATERIA MEDICA | 2012-11-14 | — | — | CN | claimed |
| CN-102015026-A | Novel nip thiazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | MERCK PATENT GMBH | 2011-04-13 | — | — | CN | claimed |
| CN-101981179-A | Yeast mutant strain and yeast extract | KOHJIN CO | 2011-02-23 | — | — | CN | claimed |