Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.36 |
| ▸ | GLRB | P48167 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.34 |
| ▸ | IL2 | P60568 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.32 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
| ▸ | TUBB | P07437 | 1/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.31 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.31 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2725903 | 0.83 | PIK3CB (0.36) | TGFBR1PIK3CBGLRA3GLRBCCNC | |
| SCHEMBL3347772 | 0.83 | GLRA3 (0.44) | PIK3CBGLRA3GLRBCCNCCDK8 | |
| SCHEMBL2724735 | 0.82 | PARP1 (0.39) | TGFBR1PIK3CBGLRA3GLRBCCNC | |
| SCHEMBL2726265 | 0.81 | TGFBR1 (0.38) | TGFBR1PIK3CBGLRA3GLRBCCNC | |
| SCHEMBL2728043 | 0.78 | KDM4B (0.39) | TGFBR1PIK3CBGLRA3GLRBIL2 | |
| SCHEMBL3353479 | 0.73 | CFTR (0.43) | PIK3CBGLRA3GLRBCCNCCDK8 | |
| SCHEMBL2725910 | 0.73 | CFTR (0.43) | PIK3CBGLRA3GLRBCCNCCDK8 | |
| SCHEMBL2724726 | 0.73 | PARP1 (0.39) | PIK3CBGLRA3GLRBIL2CFTR | |
| SCHEMBL10320333 | 0.71 | BRD4 (0.46) | PIK3CBGLRA3GLRBIL2CFTR | |
| SCHEMBL2726899 | 0.71 | ADORA2A (0.36) | TGFBR1PIK3CBGLRA3GLRBHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |