Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.47 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2726000 | 1.00 | TDP1 (0.58) | TDP1KMT2ACHI3L1KCNH2CHIT1 | |
| SCHEMBL4550904 | 1.00 | TDP1 (0.58) | TDP1KMT2ACHI3L1KCNH2CHIT1 | |
| SCHEMBL30729441 | 0.81 | LRRK2 (0.46) | TDP1KMT2ALRRK2PIK3CDPIK3CA | |
| SCHEMBL22290812 | 0.81 | LRRK2 (0.46) | TDP1KMT2ALRRK2PIK3CDPIK3CA | |
| SCHEMBL29889142 | 0.81 | LRRK2 (0.46) | TDP1KMT2ALRRK2PIK3CDPIK3CA | |
| SCHEMBL28402936 | 0.81 | LRRK2 (0.47) | TDP1KMT2AKCNH2LRRK2PIK3CD | |
| SCHEMBL31400968 | 0.81 | KDM4E (0.50) | TDP1KMT2ACHI3L1CHIT1CHIA | |
| SCHEMBL22290811 | 0.81 | LRRK2 (0.46) | TDP1KMT2ALRRK2PIK3CDPIK3CA | |
| SCHEMBL30556697 | 0.78 | ATM (0.46) | TDP1KMT2ACHI3L1KCNH2CHIT1 | |
| SCHEMBL20361408 | 0.77 | KMT2A (0.54) | TDP1KMT2ALMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133178-B2 | Alpha-7 nicotinic receptor modulators for the treatment of pain, a psychotic disorder, cognitive impairment or alzheimer'S disease | PROXIMAGEN LIMITED (GB) | 2015-09-15 | — | — | US | disclosed |
| US-20130310380-A1 | ALPHA-7 NICOTINIC RECEPTOR MODULATORS FOR THE TREATMENT OF PAIN, A PSYCHOTIC DISORDER, COGNITIVE IMPAIRMENT OR ALZHEIMER'S DISEASE | PROXIMAGEN LIMITED (GB) | 2013-11-21 | — | — | US | disclosed |
| EP-2632918-A1 | ALPHA-7 NICOTINIC RECEPTOR MODULATORS FOR THE TREATMENT OF PAIN, A PSYCHOTIC DISORDER, COGNITIVE IMPAIRMENT OR ALZHEIMER'S DISEASE | Proximagen Limited (GB) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012055942-A1 | ALPHA-7 NICOTINIC RECEPTOR MODULATORS FOR THE TREATMENT OF PAIN, A PSYCHOTIC DISORDER, COGNITIVE IMPAIRMENT OR ALZHEIMER'S DISEASE | PROXIMAGEN LIMITED (GB) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310380-A1 | ALPHA-7 NICOTINIC RECEPTOR MODULATORS FOR THE TREATMENT OF PAIN, A PSYCHOTIC DISORDER, COGNITIVE IMPAIRMENT OR ALZHEIMER'S DISEASE | CHRNA7, CHRNA10, CHRNA5 | TDP1 2296/4885KMT2A 2700/4885CHI3L1 4603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.