Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.45 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.45 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22210084 | 0.82 | CHI3L1 (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGLRRK2 | |
| SCHEMBL30729441 | 0.81 | LRRK2 (0.46) | KDM4EHTTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL2726000 | 0.81 | TDP1 (0.58) | KDM4EHTTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL2725997 | 0.81 | TDP1 (0.58) | KDM4EHTTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL4550904 | 0.81 | TDP1 (0.58) | KDM4EHTTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL29889142 | 0.81 | LRRK2 (0.46) | KDM4EHTTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL22290811 | 0.81 | LRRK2 (0.46) | KDM4EHTTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL22290812 | 0.81 | LRRK2 (0.46) | KDM4EHTTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL28402936 | 0.81 | LRRK2 (0.47) | KDM4EHTTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL23019809 | 0.75 | KMT2A (0.51) | KDM4EHTTKMT2ACHIATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | claimed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | claimed |