Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CPT2 | P23786 | 4/20 | 0.41 |
| ▸ | CPT1A | P50416 | 4/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.36 |
| ▸ | NAA50 | Q9GZZ1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2726325 | 1.00 | BACE1 (0.42) | BACE1MEN1NPC1ALDH1A1HPGD | |
| SCHEMBL2726326 | 1.00 | BACE1 (0.42) | BACE1MEN1NPC1ALDH1A1HPGD | |
| SCHEMBL2727427 | 0.98 | CPT1A (0.44) | BACE1MEN1NPC1ALDH1A1HPGD | |
| SCHEMBL2727425 | 0.98 | CPT1A (0.44) | BACE1MEN1NPC1ALDH1A1HPGD | |
| SCHEMBL2727429 | 0.98 | CPT1A (0.44) | BACE1MEN1NPC1ALDH1A1HPGD | |
| SCHEMBL2726179 | 0.93 | BACE1 (0.43) | BACE1NPC1RAB9ASMN1; SMN2CPT2 | |
| SCHEMBL2726071 | 0.93 | BACE1 (0.43) | BACE1NPC1RAB9ASMN1; SMN2CPT2 | |
| SCHEMBL2726073 | 0.93 | BACE1 (0.43) | BACE1NPC1RAB9ASMN1; SMN2CPT2 | |
| SCHEMBL10290124 | 0.93 | BACE1 (0.43) | BACE1NPC1RAB9ASMN1; SMN2CPT2 | |
| SCHEMBL2728527 | 0.92 | BACE1 (0.43) | BACE1SMN1; SMN2CPT2CPT1ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | claimed |
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |