Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 14/20 | 0.61 |
| ▸ | PIM1 | P11309 | 12/20 | 0.61 |
| ▸ | PIM3 | Q86V86 | 10/20 | 0.61 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2727078 | 1.00 | PIM2 (0.61) | PIM2PIM1PIM3CLK2LRRK2 | |
| SCHEMBL2725383 | 0.91 | PIM2 (0.58) | PIM2PIM1PIM3 | |
| SCHEMBL2725378 | 0.91 | PIM2 (0.58) | PIM2PIM1PIM3 | |
| SCHEMBL2731109 | 0.90 | PIM2 (0.57) | PIM2PIM1PIM3 | |
| SCHEMBL2731104 | 0.90 | PIM2 (0.57) | PIM2PIM1PIM3 | |
| SCHEMBL15052337 | 0.90 | PIM2 (0.55) | PIM2PIM1PIM3CLK2LRRK2 | |
| SCHEMBL15052339 | 0.90 | PIM2 (0.55) | PIM2PIM1PIM3CLK2LRRK2 | |
| SCHEMBL2731854 | 0.89 | PIM2 (0.56) | PIM2PIM1PIM3CLK2LRRK2 | |
| SCHEMBL2731856 | 0.89 | PIM2 (0.56) | PIM2PIM1PIM3CLK2LRRK2 | |
| SCHEMBL797559 | 0.88 | PIM2 (0.65) | PIM2PIM1PIM3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632462-A1 | NOVEL HETEROARYL-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | claimed |
| WO-2012058176-A1 | NOVEL HETEROARYL-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | SCHERING CORPORATION (US) | 2012-05-03 | — | — | WO | claimed |
| EP-2632462-A1 | NOVEL HETEROARYL-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058176-A1 | NOVEL HETEROARYL-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | SCHERING CORPORATION (US) | 2012-05-03 | — | — | WO | disclosed |