Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 11/20 | 0.65 |
| ▸ | PIM1 | P11309 | 10/20 | 0.65 |
| ▸ | PIM3 | Q86V86 | 8/20 | 0.65 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797560 | 1.00 | PIM2 (0.65) | PIM2PIM1PIM3CHEK1 | |
| SCHEMBL15052003 | 0.94 | PIM2 (0.62) | PIM2PIM1PIM3CHEK1 | |
| SCHEMBL15052005 | 0.94 | PIM2 (0.62) | PIM2PIM1PIM3CHEK1 | |
| SCHEMBL15051936 | 0.94 | PIM2 (0.64) | PIM2PIM1PIM3CHEK1 | |
| SCHEMBL15051938 | 0.94 | PIM2 (0.64) | PIM2PIM1PIM3CHEK1 | |
| SCHEMBL797283 | 0.94 | PIM2 (0.63) | PIM2PIM1PIM3CHEK1 | |
| SCHEMBL797282 | 0.94 | PIM2 (0.63) | PIM2PIM1PIM3CHEK1 | |
| SCHEMBL798600 | 0.93 | PIM1 (0.57) | PIM2PIM1PIM3 | |
| SCHEMBL798601 | 0.93 | PIM1 (0.57) | PIM2PIM1PIM3 | |
| SCHEMBL15052556 | 0.93 | PIM2 (0.56) | PIM2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165450-A1 | Novel Thiazol-Carboximide Derivatives as PDK1 Inhibitors | TSUI HON-CHUNG (CN) | 2013-06-27 | — | — | US | claimed |
| EP-2616451-A1 | NOVEL THIAZOL-CARBOXIMIDE DERIVATIVES AS PDK1 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-07-24 | — | — | EP | disclosed |
| US-20130165450-A1 | Novel Thiazol-Carboximide Derivatives as PDK1 Inhibitors | TSUI HON-CHUNG (CN) | 2013-06-27 | — | — | US | disclosed |
| WO-2012036974-A1 | NOVEL THIAZOL-CARBOXIMIDE DERIVATIVES AS PDK1 INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165450-A1 | Novel Thiazol-Carboximide Derivatives as PDK1 Inhibitors | PDK1, PDPK1, PDK2 | PIM2 41/4885PIM1 36/4885PIM3 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.