Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.42 |
| ▸ | PDE4A | P27815 | 7/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20562535 | 0.97 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL16935328 | 0.86 | KMT2A (0.40) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL27280475 | 0.85 | SCN9A (0.44) | PDE4DPDE4APDE4BPDE4CSCN9A | |
| SCHEMBL31535452 | 0.85 | KMT2A (0.44) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL27280537 | 0.80 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CSCN9A | |
| SCHEMBL12470349 | 0.79 | NOTUM (0.41) | KMT2APOLBMEN1 | |
| SCHEMBL31535246 | 0.78 | SCN9A (0.50) | SCN9A | |
| SCHEMBL22093026 | 0.77 | NR1I2 (0.39) | KMT2APOLBMEN1 | |
| SCHEMBL517686 | 0.77 | NOTUM (0.47) | POLB | |
| SCHEMBL16935559 | 0.75 | KAT2B (0.41) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024118564-A1 | CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | BOUNDLESS BIO, INC. (US) | 2024-06-06 | — | — | WO | disclosed |