Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 12/20 | 0.42 |
| ▸ | PDE4A | P27815 | 10/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27280551 | 0.83 | PDE4A (0.31) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL27280475 | 0.81 | SCN9A (0.44) | PDE4DPDE4APDE4BPDE4CSCN9A | |
| SCHEMBL27280448 | 0.80 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CSCN9A | |
| SCHEMBL20562535 | 0.77 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CSCN9A | |
| SCHEMBL30954373 | 0.77 | CCR1 (0.38) | PDE4B | |
| SCHEMBL20562634 | 0.74 | PDE4D (0.35) | PDE4DPDE4APDE4BPDE4CSCN9A | |
| SCHEMBL26814565 | 0.69 | SCN9A (0.46) | PDE4DPDE4APDE4BPDE4CSCN9A | |
| SCHEMBL15904302 | 0.69 | PDE4D (0.55) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL20919681 | 0.69 | PDE4D (0.55) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL72712 | 0.68 | SCN9A (0.46) | PDE4DPDE4APDE4BPDE4CSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024118564-A1 | CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | BOUNDLESS BIO, INC. (US) | 2024-06-06 | — | — | WO | disclosed |