Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.49 |
| ▸ | HRAS | P01112 | 7/20 | 0.49 |
| ▸ | ESR1 | P03372 | 7/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27282459 | 1.00 | TOP1 (0.49) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL27282453 | 0.92 | HRAS (0.48) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL10693106 | 0.84 | HRAS (0.71) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL10691121 | 0.84 | HDAC1 (0.55) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL10691569 | 0.84 | HDAC1 (0.55) | TOP1HRASESR1ESR2KDM4E | |
| Hydrochloric Acid SCHEMBL10693753 | 0.83 | KDM4E (0.72) | TOP1HRASESR1ESR2KDM4E | |
| Hydrochloric Acid SCHEMBL10693590 | 0.83 | HDAC1 (0.54) | TOP1HRASESR1ESR2KDM4E | |
| Hydrochloric Acid SCHEMBL10691977 | 0.83 | HDAC1 (0.54) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL27272389 | 0.82 | HRAS (0.54) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL27281879 | 0.82 | HRAS (0.54) | TOP1HRASESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1018825-B | Process for preparing poly-4-aminopyrrole-2-carboxamido derivatives | ERBA FARMITALIA (IT) | 1992-10-28 | — | — | CN | disclosed |