Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30278566 | 0.84 | CTNNB1 (0.43) | HPGDALDH1A1NPSR1GRIN2BMEN1 | |
| SCHEMBL10529171 | 0.84 | CTNNB1 (0.43) | HPGDALDH1A1NPSR1GRIN2BMEN1 | |
| SCHEMBL10531146 | 0.83 | KMT2A (0.50) | ALDH1A1GRIN2BMEN1KMT2AMAPT | |
| Bromide SCHEMBL10528581 | 0.82 | CTNNB1 (0.42) | HPGDALDH1A1NPSR1GRIN2BMEN1 | |
| Hydrochloric Acid SCHEMBL10531143 | 0.81 | KMT2A (0.49) | ALDH1A1NPSR1GRIN2BMEN1KMT2A | |
| Bromide SCHEMBL10528564 | 0.81 | KMT2A (0.49) | ALDH1A1GRIN2BMEN1KMT2AMAPT | |
| Bromide SCHEMBL3854391 | 0.80 | ALDH1A1 (0.48) | HPGDALDH1A1MEN1KMT2AMAPT | |
| Phosphoric Acid SCHEMBL10864885 | 0.79 | HPGD (0.40) | HPGDALDH1A1GRIN2BMEN1KMT2A | |
| SCHEMBL28841345 | 0.79 | MAPT (0.41) | ALDH1A1MAPTALOX15 | |
| Bromide SCHEMBL10528514 | 0.78 | MAPT (0.40) | ALDH1A1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1013444-B | PROCESS FOR THE PREPARATION OF A NOVEL CLASS OF HYPOGLYCEMIC AGENTS | LILLY CO ELI (US) | 1991-08-07 | — | — | CN | disclosed |
| CN-85108115-A | The preparation method of new low point hypoglycaemic agent | — | 1986-07-30 | — | — | CN | disclosed |