Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA7 | P43166 | 2/20 | 0.55 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13859331 | 0.88 | CA1 (0.57) | KDM4ECA1CA2CA7CA13 | |
| SCHEMBL2729885 | 0.85 | RXFP1 (0.70) | KDM4ECA1CA2CA7CA13 | |
| SCHEMBL3277717 | 0.83 | CA1 (0.68) | KDM4ECA1CA2CA7CA13 | |
| SCHEMBL21069948 | 0.81 | CA1 (0.48) | KDM4ECA1CA2CA7CA13 | |
| SCHEMBL2716692 | 0.80 | RXFP1 (0.55) | KDM4ECA1CA2CA7CA13 | |
| SCHEMBL2729802 | 0.79 | KDM4E (0.52) | KDM4ECA1CA2RXFP1LMNA | |
| SCHEMBL4420483 | 0.78 | RXFP1 (0.61) | RXFP1LMNAMAPTADORA2AADORA1 | |
| SCHEMBL2728689 | 0.76 | RXFP1 (0.67) | KDM4ECA1CA2CA7CA13 | |
| SCHEMBL2717013 | 0.76 | CA1 (0.69) | KDM4ECA1CA2CA7CA13 | |
| SCHEMBL10272205 | 0.76 | CA1 (0.56) | CA1CA2CA7CA13RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |