Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2728619 | 0.79 | KDM4E (0.60) | KDM4EGAAMAPTRXFP1LMNA | |
| SCHEMBL2718840 | 0.79 | RXFP1 (0.49) | KDM4ERXFP1LMNAKDRALDH1A1 | |
| SCHEMBL2718839 | 0.78 | RXFP1 (0.52) | RXFP1LMNAKDRCA1CA2 | |
| SCHEMBL2723066 | 0.77 | SYK (0.51) | KDM4EGAAMAPTCA12CA1 | |
| SCHEMBL2723063 | 0.77 | SYK (0.51) | KDM4EGAAMAPTCA12CA1 | |
| SCHEMBL2728689 | 0.76 | RXFP1 (0.67) | KDM4EGAAMAPTRXFP1LMNA | |
| SCHEMBL2718973 | 0.76 | RXFP1 (0.51) | KDM4ERXFP1LMNAALDH1A1HPGD | |
| SCHEMBL2719422 | 0.75 | RXFP1 (0.51) | RXFP1LMNACA12CA1CA9 | |
| SCHEMBL21070990 | 0.74 | CA1 (0.45) | KDM4EMAPTRXFP1LMNACA1 | |
| SCHEMBL21069948 | 0.74 | CA1 (0.48) | KDM4EMAPTRXFP1LMNACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |