SCHEMBL27290604

SCHEMBL27290604

CC(C)(C)OC(=O)N1CCC(CCc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1

nearest known ligand 0.56

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 19/20 0.56
DDB1 Q16531 15/20 0.56
GSPT1 P15170 1/20 0.53
ALDH1A1 P00352 1/20 0.46
CHRM2 P08172 1/20 0.46
OPRM1 P35372 1/20 0.46
IKZF3 Q9UKT9 1/20 0.46
CYP1A2 P05177 1/20 0.46
TSHR P16473 1/20 0.46
TDP1 Q9NUW8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20442576 0.88 CRBN (0.52) CRBNDDB1GSPT1ALDH1A1CHRM2
SCHEMBL23158378 0.87 CRBN (0.50) CRBNDDB1GSPT1ALDH1A1CHRM2
SCHEMBL23171823 0.87 CRBN (0.50) CRBNDDB1GSPT1ALDH1A1CHRM2
SCHEMBL22318094 0.87 CRBN (0.55) CRBNDDB1
SCHEMBL23302014 0.87 CRBN (0.56) CRBNDDB1GSPT1ALDH1A1CHRM2
SCHEMBL20231483 0.86 CRBN (0.53) CRBNDDB1GSPT1IKZF3
SCHEMBL30906228 0.86 CRBN (0.53) CRBNDDB1GSPT1IKZF3
SCHEMBL20234428 0.85 DDB1 (0.72) CRBNDDB1GSPT1
SCHEMBL20231478 0.85 CRBN (0.55) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL27098401 0.85 GPR119 (0.54) CRBNDDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3835298-B1 NOVEL CHROMAN DERIVATIVES HAVING ESTROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF ACCUTAR BIOTECHNOLOGY INC (US) 2024-06-26 EP disclosed