Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 11/20 | 0.46 |
| ▸ | IL1B | P01584 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27291156 | 0.94 | NLRP3 (0.49) | NLRP3IL1BIRAK4 | |
| SCHEMBL27290528 | 0.88 | NLRP3 (0.57) | NLRP3IL1B | |
| SCHEMBL28934499 | 0.86 | NLRP3 (0.47) | NLRP3IL1BIRAK4 | |
| SCHEMBL28934503 | 0.86 | NLRP3 (0.47) | NLRP3IL1BIRAK4 | |
| SCHEMBL30108801 | 0.86 | NLRP3 (0.47) | NLRP3IL1BIRAK4 | |
| SCHEMBL27290538 | 0.85 | NLRP3 (0.65) | NLRP3IL1B | |
| SCHEMBL27291305 | 0.85 | NLRP3 (0.48) | NLRP3IL1B | |
| SCHEMBL27298044 | 0.85 | NLRP3 (0.48) | NLRP3IL1B | |
| SCHEMBL27291162 | 0.84 | NLRP3 (0.55) | NLRP3IL1B | |
| SCHEMBL27291159 | 0.84 | NLRP3 (0.55) | NLRP3IL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006559-A1 | MODULATORS OF NLRP3 INFLAMMASOME AND RELATED PRODUCTS AND METHODS | Neumora Therapeutics, Inc. (US) | 2024-01-04 | — | — | WO | disclosed |