Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 8/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30923248 | 1.00 | MAPT (0.49) | MAPTSMN1; SMN2PTK2ALDH1A1ALOX15 | |
| SCHEMBL30923379 | 0.92 | PTK2 (0.49) | MAPTSMN1; SMN2PTK2ALDH1A1ALOX15 | |
| SCHEMBL27296020 | 0.92 | PTK2 (0.49) | MAPTSMN1; SMN2PTK2ALDH1A1ALOX15 | |
| SCHEMBL27292517 | 0.90 | TYK2 (0.54) | MAPTSMN1; SMN2PTK2ALDH1A1ALOX15 | |
| SCHEMBL27292739 | 0.89 | PTK2 (0.46) | MAPTSMN1; SMN2PTK2ALDH1A1ALOX15 | |
| SCHEMBL30923145 | 0.88 | CCNK (0.47) | PTK2CCNKCCNA2CDK2CCND3 | |
| SCHEMBL27292535 | 0.88 | CCNK (0.47) | PTK2CCNKCCNA2CDK2CCND3 | |
| SCHEMBL27294058 | 0.88 | TYK2 (0.55) | MAPTSMN1; SMN2PTK2ALDH1A1ALOX15 | |
| SCHEMBL30923144 | 0.87 | TYK2 (0.52) | PTK2CCNKCCNA2CDK2CCND3 | |
| SCHEMBL27289879 | 0.87 | TYK2 (0.52) | PTK2CCNKCCNA2CDK2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107658-A2 | INHIBITORS OF TYK2 | VYRNWY THERAPEUTICS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |