Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 6/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27291407 | 0.94 | SYK (0.44) | TYK2JAK1SYK | |
| SCHEMBL30923291 | 0.94 | SYK (0.44) | TYK2JAK1SYK | |
| SCHEMBL27293351 | 0.93 | NPSR1 (0.42) | TYK2JAK1MEN1KMT2ALMNA | |
| SCHEMBL27294462 | 0.88 | NPSR1 (0.42) | MEN1KMT2ALMNASYKPTK2 | |
| SCHEMBL27293130 | 0.85 | TYK2 (0.48) | TYK2JAK1 | |
| SCHEMBL30923228 | 0.85 | TYK2 (0.48) | TYK2JAK1 | |
| SCHEMBL30923196 | 0.82 | SYK (0.42) | SYKNPSR1 | |
| SCHEMBL27291912 | 0.82 | SYK (0.42) | SYKNPSR1 | |
| SCHEMBL27294494 | 0.81 | ALDH1A1 (0.42) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL30923245 | 0.80 | TYK2 (0.43) | TYK2JAK1SYKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107658-A2 | INHIBITORS OF TYK2 | VYRNWY THERAPEUTICS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |