Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | ELANE | P08246 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL308979 | 0.99 | KDM4E (0.61) | KDM4EHTTNCOA3ALDH1A1SMN1; SMN2 | |
| SCHEMBL28146940 | 0.83 | HTT (0.44) | KDM4EHTTNCOA3ALDH1A1SMN1; SMN2 | |
| SCHEMBL321639 | 0.79 | ALDH1A1 (0.83) | KDM4EHTTNCOA3ALDH1A1SMN1; SMN2 | |
| SCHEMBL31022581 | 0.79 | ALDH1A1 (0.83) | KDM4EHTTNCOA3ALDH1A1SMN1; SMN2 | |
| SCHEMBL2729633 | 0.79 | ALDH1A1 (0.83) | KDM4EHTTNCOA3ALDH1A1SMN1; SMN2 | |
| SCHEMBL28061597 | 0.77 | MCL1 (0.72) | KDM4EHTTNCOA3ALDH1A1SMN1; SMN2 | |
| SCHEMBL8402004 | 0.77 | MCL1 (0.72) | KDM4EHTTNCOA3ALDH1A1SMN1; SMN2 | |
| SCHEMBL8359452 | 0.77 | MCL1 (0.72) | KDM4EHTTNCOA3ALDH1A1SMN1; SMN2 | |
| SCHEMBL11442137 | 0.77 | MCL1 (0.72) | KDM4EHTTNCOA3ALDH1A1SMN1; SMN2 | |
| SCHEMBL12986976 | 0.76 | KDM4E (0.77) | KDM4EHTTNCOA3ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130337482-A1 | ASSAYS AND KITS TO DETERMINE GALACTOCEREBROSIDASE ACTIVITY ON SOLID SUPPORT | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2013-12-19 | — | — | US | disclosed |
| EP-2633065-A2 | ASSAYS AND KITS TO DETERMINE GALACTOCEREBROSIDASE ACTIVITY ON SOLID SUPPORT | Shire Human Genetic Therapies, Inc. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058625-A2 | ASSAYS AND KITS TO DETERMINE GALACTOCEREBROSIDASE ACTIVITY ON SOLID SUPPORT | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2012-05-03 | — | — | WO | disclosed |