Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 3/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.31 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729689 | 1.00 | BDKRB1 (0.33) | BDKRB1CTSSMEN1KMT2AALDH1A1 | |
| SCHEMBL6001352 | 0.95 | BDKRB1 (0.34) | BDKRB1CTSSMEN1KMT2AALDH1A1 | |
| SCHEMBL44689 | 0.85 | SLC34A2 (0.39) | BDKRB1CTSSMEN1KMT2AALDH1A1 | |
| SCHEMBL44690 | 0.85 | SLC34A2 (0.39) | BDKRB1CTSSMEN1KMT2AALDH1A1 | |
| SCHEMBL18482347 | 0.84 | SLC34A2 (0.35) | — | |
| SCHEMBL46828 | 0.84 | CTSS (0.36) | CTSSMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL18482345 | 0.79 | SLC34A2 (0.36) | BDKRB1TAOK1TAOK3 | |
| SCHEMBL19580050 | 0.79 | CTSS (0.39) | CTSSMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6002832 | 0.79 | CTSS (0.39) | CTSSMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6001542 | 0.77 | SLC34A2 (0.41) | BDKRB1MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |