Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.42 |
| ▸ | JAK3 | P52333 | 7/20 | 0.42 |
| ▸ | JAK2 | O60674 | 5/20 | 0.42 |
| ▸ | JAK1 | P23458 | 4/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCND2 | P30279 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27295670 | 0.89 | TYK2 (0.48) | AURKAJAK2JAK1TYK2 | |
| SCHEMBL30923150 | 0.89 | TYK2 (0.48) | AURKAJAK2JAK1TYK2 | |
| SCHEMBL30923220 | 0.82 | JAK2 (0.48) | AURKAJAK2JAK1TYK2 | |
| SCHEMBL27295711 | 0.82 | JAK2 (0.48) | AURKAJAK2JAK1TYK2 | |
| SCHEMBL30923244 | 0.82 | TYK2 (0.48) | JAK2JAK1TYK2 | |
| SCHEMBL27298988 | 0.82 | TYK2 (0.48) | JAK2JAK1TYK2 | |
| SCHEMBL27290127 | 0.82 | JAK1 (0.48) | JAK3JAK2JAK1MAPK8TYK2 | |
| Lithium SCHEMBL31017345 | 0.79 | AXL (0.51) | AURKAJAK2JAK1TYK2 | |
| Lithium SCHEMBL31017478 | 0.79 | TYK2 (0.56) | AURKAJAK2JAK1TYK2 | |
| SCHEMBL31711659 | 0.78 | JAK1 (0.51) | JAK3JAK2JAK1TYK2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107658-A2 | INHIBITORS OF TYK2 | VYRNWY THERAPEUTICS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |