Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27303889 | 0.93 | KMT2A (0.43) | EDNRAKMT2AMAPTMEN1KDM4E | |
| SCHEMBL27300785 | 0.92 | MEN1 (0.43) | EDNRAKMT2AMAPTMEN1KDM4E | |
| SCHEMBL27296603 | 0.87 | MEN1 (0.47) | KMT2AMAPTMEN1KDM4ESLC6A2 | |
| SCHEMBL27295612 | 0.84 | DRD1 (0.35) | KMT2AMAPTMEN1GAASIGMAR1 | |
| SCHEMBL27346085 | 0.83 | GAA (0.39) | KMT2AMEN1KDM4EGAASIGMAR1 | |
| SCHEMBL14701152 | 0.80 | MEN1 (0.45) | EDNRAKMT2AMAPTMEN1KDM4E | |
| SCHEMBL13588376 | 0.78 | KMT2A (0.44) | EDNRAKMT2AMAPTMEN1KDM4E | |
| SCHEMBL8304137 | 0.74 | HTR2A (0.46) | KMT2AMEN1 | |
| SCHEMBL27359306 | 0.74 | HDAC9 (0.55) | KMT2AMAPTNPC1SIGMAR1MAPK1 | |
| SCHEMBL9543856 | 0.70 | EDNRA (0.46) | EDNRAKMT2AMAPTMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1034569-C | ET (ENDOTHELIN) receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1997-04-16 | — | — | CN | disclosed |
| CN-1073161-A | ET (ENDOTHELIN) receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1993-06-16 | — | — | CN | disclosed |