Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035580 | 0.86 | DRD1 (0.38) | HTR2APTGS2KMT2AALDH1A1MEN1 | |
| SCHEMBL8601902 | 0.86 | DRD1 (0.38) | HTR2APTGS2KMT2AALDH1A1MEN1 | |
| SCHEMBL8602566 | 0.86 | DRD1 (0.38) | HTR2APTGS2KMT2AALDH1A1MEN1 | |
| SCHEMBL8601315 | 0.86 | DRD1 (0.38) | HTR2APTGS2KMT2AALDH1A1MEN1 | |
| SCHEMBL8601899 | 0.86 | DRD1 (0.38) | HTR2APTGS2KMT2AALDH1A1MEN1 | |
| SCHEMBL9035567 | 0.86 | DRD1 (0.38) | HTR2APTGS2KMT2AALDH1A1MEN1 | |
| SCHEMBL8602565 | 0.86 | DRD1 (0.38) | HTR2APTGS2KMT2AALDH1A1MEN1 | |
| SCHEMBL11261460 | 0.83 | HTR2A (0.49) | HTR2ANR3C1PTGS2KMT2AALDH1A1 | |
| SCHEMBL11492800 | 0.83 | HTR2A (0.44) | HTR2AAKR1C1NR3C1PTGS2KMT2A | |
| SCHEMBL8659665 | 0.81 | HTR2A (0.49) | HTR2ATHRBTDP1AKR1C1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0707579-B1 | PIPERIDINYL SUBSTITUTED METHANOANTHRACENES AS D1/D2-ANTAGONISTS AND 5HT2-SEROTANIN-ANTAGONISTS | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5719166-A | TREATING PSYCHOSES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1998-02-17 | — | — | US | disclosed |
| US-5681840-A | ANTIDOPAMINERGIC AGENTS | ZENECA LIMITED (GB) | 1997-10-28 | — | — | US | disclosed |
| EP-0532177-B1 | Methanoanthracenes as dopamine antagonists | ZENECA LTD (GB) | 1996-10-16 | — | — | EP | disclosed |
| EP-0532178-B1 | Methanoanthracenes as dopamine antagonists | ZENECA LTD (GB) | 1996-10-16 | — | — | EP | disclosed |
| EP-0533344-B1 | Methanoanthracenes as dopamine antagonists | ZENECA LTD (GB) | 1996-10-16 | — | — | EP | disclosed |
| US-5550136-A | ANTAGONISTS OF DOPAMINE D-2 RECEPTORS | ZENECA LIMITED (GB) | 1996-08-27 | — | — | US | disclosed |
| US-5512575-A | ANTISEROTONINE AGENT | ZENECA LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| EP-0707579-A1 | PIPERIDINYL SUBSTITUTED METHANOANTHRACENES AS D1/D2-ANTAGONISTS AND 5HT2-SEROTANIN-ANTAGONISTS | ZENECA LIMITED (GB) | 1996-04-24 | — | — | EP | disclosed |
| US-5455246-A | Treating neuropsychiatric disorders | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1995-10-03 | — | — | US | disclosed |
| US-5399568-A | Dopamine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-03-21 | — | — | US | disclosed |
| WO-1995001974-A1 | PIPERIDINYL SUBSTITUTED METHANOANTHRACENES AS D1/D2-ANTAGONISTS AND 5HT2-SEROTANIN-ANTAGONISTS | ZENECA LIMITED (GB) | 1995-01-19 | — | — | WO | disclosed |
| US-5266570-A | Neuropsychiatric disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-11-30 | — | — | US | disclosed |
| EP-0533344-A1 | Methanoanthracenes as dopamine antagonists | ZENECA LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |
| EP-0532178-A1 | Methanoanthracenes as dopamine antagonists | ZENECA LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |
| EP-0532177-A1 | Methanoanthracenes as dopamine antagonists | ZENECA LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |
| US-4358620-A | 9-Formyl-9,10-dihydro-9,10-methanoanthracene | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-11-09 | — | — | US | disclosed |
| US-4224344-A | Organic tricyclic compounds | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-09-23 | — | — | US | disclosed |