Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731133 | 0.88 | PTGS1 (0.47) | PTGS1PTGS2DUSP3MAPTMEN1 | |
| SCHEMBL2721239 | 0.87 | MAPT (0.44) | PTGS1PTGS2DUSP3MAPTMEN1 | |
| SCHEMBL2730192 | 0.87 | DUSP3 (0.47) | PTGS1PTGS2DUSP3MAPTMEN1 | |
| SCHEMBL2729879 | 0.86 | PTGS1 (0.41) | PTGS1PTGS2DUSP3MAPTMEN1 | |
| SCHEMBL2732395 | 0.85 | PTGS1 (0.59) | PTGS1PTGS2DUSP3MAPTMEN1 | |
| SCHEMBL2729864 | 0.84 | PTGS1 (0.41) | PTGS1PTGS2DUSP3MAPTMEN1 | |
| SCHEMBL2732046 | 0.83 | PTGS1 (0.43) | PTGS1PTGS2DUSP3MAPTMEN1 | |
| SCHEMBL2732508 | 0.83 | PTGS1 (0.45) | PTGS1PTGS2DUSP3MAPTMEN1 | |
| SCHEMBL2729884 | 0.83 | MAPT (0.48) | PTGS1PTGS2DUSP3MAPTMEN1 | |
| SCHEMBL2730369 | 0.83 | PTGS1 (0.41) | PTGS1PTGS2DUSP3MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052395-A1 | ISOXAZOLE DERIVATIVES USED AS OESTROGEN MODULATORS | N. V. ORGANON (NL) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012052395-A1 | ISOXAZOLE DERIVATIVES USED AS OESTROGEN MODULATORS | N. V. ORGANON (NL) | 2012-04-26 | — | — | WO | disclosed |