⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27300199 | 0.89 | HRH3 (0.36) | — | |
| SCHEMBL27307958 | 0.87 | TSHR (0.31) | — | |
| SCHEMBL27307934 | 0.86 | KMT2A (0.32) | — | |
| SCHEMBL27307848 | 0.84 | — | — | |
| SCHEMBL27299893 | 0.83 | HRH3 (0.37) | — | |
| SCHEMBL27421244 | 0.82 | HRH3 (0.36) | — | |
| SCHEMBL27427821 | 0.82 | — | — | |
| SCHEMBL27307629 | 0.82 | CYP2D6 (0.30) | — | |
| SCHEMBL27310502 | 0.81 | OPRM1 (0.33) | — | |
| SCHEMBL27300205 | 0.81 | HRH3 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240216516-A1 | GLUTARIMIDE-CONTAINING KRAS-MUTANT DEGRADER COMPOUNDS AND USES THEREOF | TIGER BIOTHERAPEUTICS INC. | 2024-07-04 | — | — | US | disclosed |