Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1002 | 0.87 | SMN1; SMN2 (0.40) | SMN1; SMN2PKMKDM4EMAPTALDH1A1 | |
| SCHEMBL939 | 0.77 | SMN1; SMN2 (0.38) | SMN1; SMN2PKMKDM4EMAPTALDH1A1 | |
| SCHEMBL8951990 | 0.73 | PKM (0.44) | SMN1; SMN2PKMKDM4EMAPTALDH1A1 | |
| SCHEMBL1730 | 0.72 | PKM (0.61) | PKMKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL9383028 | 0.72 | SMN1; SMN2 (0.35) | SMN1; SMN2PKM | |
| SCHEMBL19224194 | 0.70 | PKM (0.42) | SMN1; SMN2PKMKDM4EMAPTALDH1A1 | |
| SCHEMBL28376978 | 0.69 | PKM (0.41) | SMN1; SMN2PKMKDM4EMAPTALDH1A1 | |
| SCHEMBL26664506 | 0.67 | PKM (0.42) | SMN1; SMN2PKMKDM4EMAPTALDH1A1 | |
| SCHEMBL27312546 | 0.67 | SMN1; SMN2 (0.61) | SMN1; SMN2PKMMAPTALDH1A1LMNA | |
| SCHEMBL14376855 | 0.66 | SMN1; SMN2 (0.46) | SMN1; SMN2PKMMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1028758-C | Pyrazolopyrimidinone antianginal agents | PFIZER (US) | 1995-06-07 | — | — | CN | disclosed |
| CN-1057464-A | Pyrazolopyrimidinoneantianginal antianginal agents | PFIZER (US) | 1992-01-01 | — | — | CN | disclosed |
| CN-1045783-A | Diaza class anti-allergy medicament | PFIZER (US) | 1990-10-03 | — | — | CN | disclosed |