Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 14/20 | 0.69 |
| ▸ | PIM3 | Q86V86 | 12/20 | 0.69 |
| ▸ | PIM1 | P11309 | 11/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731159 | 1.00 | PIM2 (0.69) | PIM2PIM3PIM1CHEK1 | |
| SCHEMBL2732222 | 0.88 | PIM2 (0.61) | PIM2PIM3PIM1CHEK1 | |
| SCHEMBL2732229 | 0.88 | PIM2 (0.61) | PIM2PIM3PIM1CHEK1 | |
| SCHEMBL14206464 | 0.83 | CHEK1 (0.73) | PIM2PIM3PIM1CHEK1 | |
| SCHEMBL2727564 | 0.83 | CHEK1 (0.60) | PIM2PIM3PIM1CHEK1 | |
| SCHEMBL2727568 | 0.83 | CHEK1 (0.60) | PIM2PIM3PIM1CHEK1 | |
| SCHEMBL2732276 | 0.82 | PIM2 (0.60) | PIM2PIM3PIM1CHEK1 | |
| SCHEMBL2732278 | 0.82 | PIM2 (0.60) | PIM2PIM3PIM1CHEK1 | |
| SCHEMBL2693258 | 0.81 | PIM2 (1.00) | PIM2PIM3PIM1CHEK1 | |
| SCHEMBL2693265 | 0.81 | PIM2 (1.00) | PIM2PIM3PIM1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632462-A1 | NOVEL HETEROARYL-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | claimed |
| WO-2012058176-A1 | NOVEL HETEROARYL-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | SCHERING CORPORATION (US) | 2012-05-03 | — | — | WO | claimed |
| EP-2632462-A1 | NOVEL HETEROARYL-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058176-A1 | NOVEL HETEROARYL-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | SCHERING CORPORATION (US) | 2012-05-03 | — | — | WO | disclosed |