Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599723 | 0.83 | LMNA (0.37) | LMNAPKMNPSR1ALDH1A1KDM4E | |
| SCHEMBL2011873 | 0.79 | LMNA (0.45) | LMNAPKMNPSR1ALDH1A1KDM4E | |
| SCHEMBL12191288 | 0.77 | ERN1 (0.37) | LMNAALDH1A1POLBNPC1KMT2A | |
| SCHEMBL5961698 | 0.77 | LMNA (0.51) | LMNAPKMNPSR1ALDH1A1KDM4E | |
| SCHEMBL4239500 | 0.76 | MEN1 (0.35) | LMNAALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL10892120 | 0.76 | LMNA (0.58) | LMNAALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL2435227 | 0.75 | LMNA (0.34) | LMNAALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL4560481 | 0.75 | LMNA (0.39) | LMNAPKMNPSR1ALDH1A1KDM4E | |
| SCHEMBL12035984 | 0.75 | ERN1 (0.40) | LMNANPSR1ALDH1A1KDM4EMAPT | |
| SCHEMBL435089 | 0.74 | LMNA (0.49) | LMNAPKMNPSR1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523277-B1 | SUBSTITUTED PYRROLIDINES AS CFTR MODULATORS | ABBVIE OVERSEAS SARL (LU) | 2021-06-30 | — | — | EP | disclosed |
| EP-3523293-B1 | SUBSTITUTED PYRROLIDINES AND THEIR USE IN THE TREATMENT OF CYSTIC FIIBROSIS | ABBVIE OVERSEAS SARL (LU) | 2021-06-16 | — | — | EP | disclosed |
| US-20190315687-A1 | Substituted Pyrrolidines and Methods of Use | ABBVIE S.Á.R.L. (LU) | 2019-10-17 | — | — | US | disclosed |
| US-10399940-B2 | Substituted pyrrolidines and methods of use | ABBVIE S.Á.R.L. (LU) | 2019-09-03 | — | — | US | disclosed |
| EP-3523293-A1 | SUBSTITUTED PYRROLIDINES AND THEIR USE IN THE TREATMENT OF CYSTIC FIIBROSIS | Abbvie S.a.r.l. (LU) | 2019-08-14 | — | — | EP | disclosed |
| EP-3523277-A1 | SUBSTITUTED PYRROLIDINES AS CFTR MODULATORS | Abbvie S.a.r.l. (LU) | 2019-08-14 | — | — | EP | disclosed |
| US-9981910-B2 | Substituted pyrrolidines and methods of use | ABBVIE S.Á.R.L. (LU) | 2018-05-29 | — | — | US | disclosed |
| WO-2018065921-A1 | SUBSTITUTED PYRROLIDINES AS CFTR MODULATORS | ABBVIE S.Á.R.L. (LU) | 2018-04-12 | — | — | WO | disclosed |
| US-20180099932-A1 | Substituted Pyrrolidines and Methods of Use | GALAPAGOS NV (BE) | 2018-04-12 | — | — | US | disclosed |
| US-20180099931-A1 | Substituted Pyrrolidines and Methods of Use | ABBVIE S.Á.R.L. (LU) | 2018-04-12 | — | — | US | disclosed |
| EP-1242410-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-09-25 | — | — | EP | disclosed |
| EP-0826684-B1 | PIPERIDINE DERIVATIVES | HISAMITSU PHARMACEUTICAL CO (JP) | 2001-11-21 | — | — | EP | disclosed |
| WO-2001046174-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |
| CN-1224423-A | Process for preparing 2,3-dihydro-2-methyl-2-alkyl-benzofuran derivs | KOREA RES INST CHEM TECH (KR) | 1999-07-28 | — | — | CN | disclosed |
| EP-0912538-A1 | PROCESS FOR PREPARING 2,3-DIHYDRO-2-METHYL-2-ALKYLBENZOFURAN DERIVATIVES | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1999-05-06 | — | — | EP | disclosed |
| US-5886011-A | TACHYKININ UNDECAPEPTIDE ANTAGONIST, USEFUL FOR TREATING ASTHMA, OR REMEDY FOR DISEASES ASSOCIATED WITH CENTRAL NERVOUS SYSTEM, DIGESTIVE SYSTEM AND CIRULATORY STYSTEM, AND VARIETY OF PAINS OR INFLAMMATION | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0826684-A1 | PIPERIDINE DERIVATIVES | Hisamitsu Pharmaceutical Co., Inc. (JP) | 1998-03-04 | — | — | EP | disclosed |
| WO-1997047615-A1 | PROCESS FOR PREPARING 2,3-DIHYDRO-2-METHYL-2-ALKYLBENZOFURAN DERIVATIVES | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1997-12-18 | — | — | WO | disclosed |
| US-4748186-A | NEMATOCIDES, ANTHELMINTICS | FMC CORPORATION (US) | 1988-05-31 | — | — | US | disclosed |
| WO-1988000183-A1 | S-TRIFLUOROBUTENYL DERIVATIVES AND PESTICIDAL USES | FMC CORPORATION (US) | 1988-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180099931-A1 | Substituted Pyrrolidines and Methods of Use | CFTR, PKD1, PKD2 | LMNA 3142/4885PKM 743/4885NPSR1 358/4885 |
| US-20190315687-A1 | Substituted Pyrrolidines and Methods of Use | CFTR, PKD1, PKD2 | LMNA 3325/4885PKM 793/4885NPSR1 319/4885 |
| US-10399940-B2 | Substituted pyrrolidines and methods of use | CFTR, PKD1, PKD2 | LMNA 3325/4885PKM 793/4885NPSR1 319/4885 |
| US-20180099932-A1 | Substituted Pyrrolidines and Methods of Use | CFTR, PKD1, PKD2 | LMNA 3325/4885PKM 793/4885NPSR1 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.