Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.51 |
| ▸ | WIZ | O95785 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | IKZF2 | Q9UKS7 | 4/20 | 0.47 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.46 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20046362 | 0.92 | CRBN (0.59) | CRBNCSNK1A1WIZESR1IKZF2 | |
| SCHEMBL24735001 | 0.92 | WIZ (0.52) | CRBNWIZIKZF2IKZF3GSPT1 | |
| SCHEMBL29841367 | 0.92 | WIZ (0.52) | CRBNWIZIKZF2IKZF3GSPT1 | |
| SCHEMBL31047983 | 0.92 | WIZ (0.52) | CRBNWIZIKZF2IKZF3GSPT1 | |
| SCHEMBL29547522 | 0.89 | CRBN (0.56) | CRBNCSNK1A1WIZIKZF2DDB1 | |
| SCHEMBL30720169 | 0.89 | CRBN (0.56) | CRBNCSNK1A1WIZIKZF2DDB1 | |
| SCHEMBL30720192 | 0.89 | CRBN (0.56) | CRBNCSNK1A1WIZIKZF2DDB1 | |
| SCHEMBL31611548 | 0.89 | CRBN (0.56) | CRBNCSNK1A1WIZIKZF2DDB1 | |
| SCHEMBL20046704 | 0.89 | CRBN (0.56) | CRBNCSNK1A1WIZIKZF2DDB1 | |
| SCHEMBL27301548 | 0.89 | CRBN (0.56) | CRBNCSNK1A1WIZIKZF2DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024077244-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISORDERS | HOTSPOT THERAPEUTICS, INC. (US) | 2024-04-11 | — | — | WO | disclosed |