WIZ — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL20128909	0.59	6/20
SCHEMBL20230997	0.58	6/20
SCHEMBL21618055	0.56	6/20
SCHEMBL20046428	0.54	6/20
SCHEMBL20766611	0.53	6/20
SCHEMBL20766615	0.53	6/20
SCHEMBL21618063	0.52	6/20
SCHEMBL20231105	0.51	6/20
SCHEMBL21464529	0.51	6/20
SCHEMBL21618072	0.51	6/20
SCHEMBL21618108	0.51	6/20
SCHEMBL21618159	0.50	6/20
SCHEMBL21618166	0.50	6/20
SCHEMBL21618024	0.49	6/20
SCHEMBL21618065	0.49	6/20
SCHEMBL21618156	0.49	6/20
SCHEMBL21618174	0.49	6/20
SCHEMBL21618088	0.49	6/20
SCHEMBL21618193	0.48	6/20
SCHEMBL21618146	0.48	6/20

Clinical trials — most relevant to WIZ by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Gene Therapy for Wiskott-Aldrich Syndrome	PHASE1/PHASE2	COMPLETED
An Open-Label Study of Oral NNZ-2591 in Prader-Willi Syndrome (PWS-001)	PHASE2	WITHDRAWN
An Open-Label Study of Oral NNZ-2591 in Pitt Hopkins Syndrome (PTHS-001)	PHASE2	COMPLETED
Better Delineation of BCL11B Related Phenotype and Epigenetic Signature.	nan	COMPLETED
Better Delineation of YY1 Related Phenotype and Epigenetic Signatures.	nan	UNKNOWN
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions	nan	COMPLETED
Whole Coffee Fruit Concentrate Pilot Study 1	nan	COMPLETED
Study of Genetic and Molecular Defects in Primary Immunodeficiency Disorders	nan	UNKNOWN
Better Delineation of DDX3X Related Phenotype and Epigenetic Signature.	nan	UNKNOWN
I-Tracking Neurodegeneration in Early Wolfram Syndrome	nan	COMPLETED
Phenomics and Genomics of Clozapine Pharmacotherapy	nan	UNKNOWN
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature.	nan	UNKNOWN
Molecular Analysis of Microphthalmia/Anophthalmia	nan	COMPLETED
Molecular and Clinical Studies of Primary Immunodeficiency Diseases	nan	UNKNOWN
COPENHAGEN Minipuberty Study	nan	UNKNOWN
Danish Diabetes Birth Registry 2	nan	RECRUITING
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Added Value of the Oculomotor and Cognitive Examination in the Management of Patients With ADHD	nan	UNKNOWN
NICUSeq: A Trial to Evaluate the Clinical Utility of Human Whole Genome Sequencing (WGS) Compared to Standard of Care in Acute Care Neonates and Infants	nan	COMPLETED
European Childhood Obesity Project: Early Programming by Infant Nutrition?	nan	UNKNOWN
Inter-regional Project of the Great Western Exploration Approach for Exome Molecular Causes Severe Intellectual Disability Isolated or Syndromic	nan	COMPLETED
Digital Therapeutic vs Psychoeducation for Management of Mild to Moderate Depression in Adolescents	nan	COMPLETED
Rapid Whole Genome Sequencing Study	nan	ENROLLING_BY_INVITATION
Whole Exome Sequencing in Prenatal Diagnosis of Agenesis of the Corpus Callosum	nan	COMPLETED
Determinant of Fetal Growth Retardation After Sleeve Gastrectomy: Involvement of Ghrelin	nan	UNKNOWN
Defining the Brain Phenotype of Children With Williams Syndrome	nan	RECRUITING
Genomic Medicine for Ill Neonates and Infants (The GEMINI Study)	nan	COMPLETED
Cooperative Parent Mediated Therapy in Children With Fragile X Syndrome and Williams Syndrome	nan	UNKNOWN
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory	nan	COMPLETED
Further Delineation of the De Santo Shinawi Syndrome Phenotype Using a Series of Individuals Carrying a Pathogenic Variant of the WAC Gene	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a WIZ binder may also engage these)

Protein	Name	Similarity
O88286	—	0.990	O88286 →
Q9BUA3	—	0.985	Q9BUA3 →
P0CG20	—	0.983	P0CG20 →
Q8TBE0	—	0.983	Q8TBE0 →
Q497V6	—	0.982	Q497V6 →
Q9NR83	—	0.981	Q9NR83 →
Q9GMA3	—	0.981	Q9GMA3 →
Q8N1G0	—	0.981	Q8N1G0 →
Q9NZR4	—	0.980	Q9NZR4 →
Q8IX15	—	0.980	Q8IX15 →
Q8BSN5	—	0.980	Q8BSN5 →
Q80W88	—	0.980	Q80W88 →
Q6ZMQ8	—	0.980	Q6ZMQ8 →
Q2MHN3	—	0.980	Q2MHN3 →
O14529	—	0.980	O14529 →
Q9JMG6	—	0.980	Q9JMG6 →
Q05AH6	—	0.980	Q05AH6 →
Q5TGY3	—	0.979	Q5TGY3 →
Q96RK0	—	0.979	Q96RK0 →
A6NNL0	—	0.979	A6NNL0 →
Q5JPB2	—	0.979	Q5JPB2 →
P48382	—	0.979	P48382 →
Q6AY75	—	0.979	Q6AY75 →
Q9WVH3	—	0.979	Q9WVH3 →
Q92610	—	0.979	Q92610 →
O35615	—	0.979	O35615 →
Q6PJ61	—	0.979	Q6PJ61 →
MSL1	Male-specific lethal 1 homolog	0.978	landscape →
Q9D2D7	—	0.978	Q9D2D7 →
LMTK3	Serine/threonine-protein kinase LMTK3	0.978	landscape →