Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 9/20 | 0.47 |
| ▸ | MERTK | Q12866 | 7/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 11/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27315234 | 0.88 | RET (0.56) | RETAXLMERTKTYRO3 | |
| SCHEMBL27315239 | 0.88 | RET (0.51) | RETAXLMERTKTYRO3AURKA | |
| SCHEMBL27315227 | 0.81 | NTRK1 (0.55) | RETAXLMERTKAURKAAURKB | |
| SCHEMBL27315264 | 0.80 | AXL (0.48) | AXLMERTKTYRO3AURKAAURKB | |
| SCHEMBL29927002 | 0.78 | ACVRL1 (0.46) | AXLMERTKTYRO3 | |
| SCHEMBL27315088 | 0.76 | CSNK2A2 (0.43) | CSNK2A2CSNK2A1 | |
| SCHEMBL29927100 | 0.75 | ERBB2 (0.59) | — | |
| SCHEMBL27315133 | 0.75 | ACVRL1 (0.45) | AXLMERTKTYRO3CSNK2A2CSNK2A1 | |
| SCHEMBL27315260 | 0.74 | F2 (0.39) | RET | |
| SCHEMBL27315078 | 0.69 | ACVRL1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4611900-A1 | RET-LDD PROTEIN INHIBITORS | Bristol-Myers Squibb Company (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024097980-A1 | RET-LDD PROTEIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-05-10 | — | — | WO | disclosed |
| WO-2024097980-A1 | RET-LDD PROTEIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-05-10 | — | — | WO | disclosed |