Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.54 |
| ▸ | CDK1 | P06493 | 7/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL273533 | 0.88 | CDK2 (0.68) | CDK2KCNH2CDK1 | |
| SCHEMBL272487 | 0.88 | CDK2 (0.55) | CDK2KCNH2CDK1HDAC1 | |
| SCHEMBL274273 | 0.84 | HDAC1 (0.54) | KCNH2HDAC1 | |
| SCHEMBL273354 | 0.84 | HDAC1 (0.48) | CDK2KCNH2CDK1HDAC1 | |
| SCHEMBL274092 | 0.83 | HDAC1 (0.47) | CDK2KCNH2CDK1HDAC1 | |
| SCHEMBL273757 | 0.82 | CDK2 (0.65) | CDK2KCNH2CDK1 | |
| SCHEMBL274376 | 0.81 | CDK2 (0.62) | CDK2KCNH2CDK1 | |
| SCHEMBL272841 | 0.80 | CDK2 (0.58) | CDK2KCNH2CDK1 | |
| SCHEMBL273627 | 0.79 | CDK2 (0.66) | CDK2KCNH2CDK1 | |
| SCHEMBL273291 | 0.79 | CDK2 (0.60) | CDK2KCNH2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134000-B2 | Imidazolyl pyrimidine inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-03-13 | — | — | US | claimed |
| JP-2011528039-A | — | — | 2011-11-10 | — | — | JP | claimed |
| WO-2010009139-A2 | IMIDAZOLYL PYRIMIDINE INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | claimed |
| US-20100009990-A1 | IMIDAZOLYL PYRIMIDINE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2010-01-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009990-A1 | IMIDAZOLYL PYRIMIDINE INHIBITOR COMPOUNDS | HDAC1, CDK9, CDK2 | CDK2 3/4885KCNH2 3847/4885CDK1 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.