Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 5/20 | 0.51 |
| ▸ | TNKS | O95271 | 4/20 | 0.51 |
| ▸ | PARP1 | P09874 | 4/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL277870 | 0.85 | TNKS (0.56) | GUSBTNKSPARP1TNKS2NPC1 | |
| SCHEMBL11920135 | 0.82 | KDM4E (0.54) | GUSBTNKSPARP1TNKS2NPC1 | |
| SCHEMBL277606 | 0.78 | MET (0.47) | TNKSPARP1TNKS2NPC1RAB9A | |
| SCHEMBL259489 | 0.78 | GUSB (0.74) | GUSBTNKSPARP1TNKS2NPC1 | |
| SCHEMBL11919793 | 0.78 | GUSB (0.55) | GUSBTNKSTNKS2NPC1RAB9A | |
| SCHEMBL12811999 | 0.77 | PARP1 (0.47) | GUSBTNKSPARP1TNKS2HPGD | |
| SCHEMBL259248 | 0.76 | TNKS (0.58) | GUSBTNKSPARP1TNKS2NPC1 | |
| SCHEMBL873906 | 0.76 | TNKS (0.71) | GUSBTNKSPARP1TNKS2NPC1 | |
| SCHEMBL259542 | 0.74 | KDM4E (0.56) | GUSBTNKSPARP1TNKS2NPC1 | |
| SCHEMBL11919210 | 0.74 | GUSB (0.50) | GUSBTNKSTNKS2CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067586-B2 | Fused heteroaryl derivatives | ASTELLAS PHARMA INC. (JP) | 2011-11-29 | — | — | US | disclosed |
| US-20100137584-A1 | FUSED HETEROARYL DERIVATIVES | HAYAKAWA MASAHIKO | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137584-A1 | FUSED HETEROARYL DERIVATIVES | PIK3CD, PIK3R3, PIK3C2A | GUSB 1751/4885TNKS 578/4885PARP1 1165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.