SCHEMBL27317136

SCHEMBL27317136

Cn1ncc(-c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c1-c1ccccc1Cl

nearest known ligand 0.59

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 12/20 0.59
▸ IKZF1 Q13422 2/20 0.52
▸ IKZF2 Q9UKS7 6/20 0.49
▸ CSNK1A1 P48729 1/20 0.49
▸ GSPT1 P15170 1/20 0.46
▸ DDB1 Q16531 1/20 0.46
▸ IKZF3 Q9UKT9 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27317437 0.91 CRBN (0.55) CRBNIKZF1IKZF2GSPT1DDB1
SCHEMBL27317314 0.90 CRBN (0.60) CRBNIKZF1IKZF2CSNK1A1
SCHEMBL27316087 0.90 CRBN (0.60) CRBNIKZF1IKZF2CSNK1A1
SCHEMBL27316287 0.90 CRBN (0.56) CRBNIKZF1IKZF2CSNK1A1GSPT1
SCHEMBL27316290 0.90 CRBN (0.53) CRBNIKZF1IKZF2GSPT1DDB1
SCHEMBL27315977 0.90 CRBN (0.59) CRBNIKZF1IKZF2CSNK1A1
SCHEMBL27317068 0.90 CRBN (0.59) CRBNIKZF1IKZF2CSNK1A1DDB1
SCHEMBL27217151 0.89 CRBN (0.60) CRBNIKZF1IKZF2CSNK1A1
SCHEMBL27316807 0.89 CRBN (0.58) CRBNIKZF1IKZF2CSNK1A1
SCHEMBL27316089 0.89 CRBN (0.56) CRBNIKZF1IKZF2GSPT1DDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024054832-A1 CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. (US) 2024-03-14 — — WO disclosed
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